NMN works at the cellular level — it supports NAD+ levels, which help maintain mitochondrial function. Some people notice improved energy and mental clarity within 2–4 weeks. For most, the effect builds over 8–12 weeks of consistent daily use.

If you have not noticed anything after 30 days, do not stop. Research routines are typically assessed over 12 weeks. Read our guide on why 90 days is the right assessment window.

Either works, but we recommend taking NMN in the morning on an empty stomach or with a light, low-fat meal. This supports consistent absorption. Avoid taking with a large high-fat meal, which can slow gastric emptying.

TMG (Trimethylglycine) is recommended alongside NMN. NMN raises NAD+ through a pathway that uses methyl groups. Replenishing that methyl pool supports healthy methylation, and TMG helps do exactly that.

Take TMG 600mg with your NMN each morning. Read the full explanation here.

500mg is the established starting amount — aligned with commonly studied daily amounts. 600mg is for those stepping up after a completed routine at 500mg, or for those with higher body mass or more demanding lifestyles.

If you are new to NMN, start at 500mg. Move to 600mg on a later cycle. Full comparison here.

NMN has been well tolerated in human studies to date. It is a naturally occurring compound present in small amounts in foods including edamame, broccoli and avocado.

As with any supplement, if you are pregnant, breastfeeding, or taking prescription medication — particularly blood pressure or blood glucose medication — consult your GP before starting.

HPMC (hydroxypropyl methylcellulose) is the pharmaceutical-grade capsule standard — vegan, moisture-resistant, and free from the cross-linking issue that causes gelatin capsules to harden and resist dissolution. HPMC dissolves consistently every time.

Read our full explanation on why capsule shell type matters.

Yes. NMN pairs well with the following, each targeting a different area:

• TMG 600mg — methyl donor support (recommended with every NMN routine)
• R-ALA 600mg — an antioxidant companion
• Lion's Mane 500mg — studied for NGF, adding a cognitive layer

No known negative interactions with the Alchemy Fit product range.